A recent study conducted by researchers affiliated with the University of Colorado shows that water-soluble cannabidiol products provide the best absorption of CBD, revealing new practices for consumers seeking the benefits of the popular cannabinoid. The study, which was published last month in the peer-reviewed journal Nutrients , also examined the impact that cannabidiol has on digestion and found that CBD products are best absorbed when consumed with food, among other findings.
The study, which was conducted in conjunction with Colorado State University's Department of Health and Exercise Science, compared the absorption of five different CBD formulations in 14 male test subjects. The products tested included CBD diluted in medium-chain triglycerides (MCT), coconut oil, CBD isolate, and three different water-soluble CBD formulations. The study's goal was to document how each of these CBD products entered and left the bloodstream, and at what rate. The study also analyzed how the formulations interacted with liver function and whether there was evidence that food intake and metabolism were affected by the products.
Water-soluble CBD has the best absorption
The study found that water-soluble CBD preparations demonstrated better pharmacokinetics compared to oil-based CBD. One of the water-soluble CBD preparations used in the study was created with a special patented technology from NextEvo Naturals , which has been shown to significantly improve bioavailability. John McDonagh, the company’s CEO, said the study opens up new possibilities for consumers on how to get the most out of their CBD products.
“While the potential health benefits of CBD are widely publicized, this new material suggests that consumers should carefully consider pharmacokinetic differences between commercial CBD formulations, such as how the CBD you ingest is absorbed into the body,” McDonagh said in a statement from NextEvo . “Our goal was to demonstrate that our product formulations can offer real-world CBD benefits by quickly and efficiently entering the bloodstream.”
The study results, which NextEvo notes have not been evaluated by the U.S. Food and Drug Administration, show a greater than 500% difference in peak blood concentrations between water-soluble CBD formulations compared to oil-based formulations and unformulated CBD isolate. This difference represents a significant difference in the body’s ability to absorb and process CBD, which is necessary to reap the potential health and wellness benefits of the cannabinoid.
Taking CBD with food increases absorption
The results also showed that consuming water-soluble CBD with food significantly increased the body’s absorption of CBD and altered early insulin and triglyceride responses. Six hours after consumption, the concentration of CBD in the bloodstream was three times higher when consumed with food compared to when the product was taken in a fasted state. David Chernoff, MD, chief medical officer at NextEvo , says the study reveals the potential positive effects of CBD on insulin and triglyceride levels.
“The results of our study show that within 30 minutes of a meal, CBD appears to reduce insulin and triglyceride levels. The exact mechanism for how CBD affects insulin and triglyceride levels is unclear, as CBD levels 30 minutes after a meal are very low,” Chernoff wrote in an email. “What can be concluded from these findings is that CBD may have a beneficial effect on how fats and sugars are metabolized after a meal, so CBD may be useful for supporting healthy glucose and lipid metabolism.”
Researchers have long debated whether eating food or fasting can affect the absorption of CBD into the bloodstream. Some have found that it helps to eat when taking fat-soluble CBD, but the new study suggests that taking water-soluble CBD products with food will provide the most benefit. “We found that the best way for users to take CBD is in a product containing a water-soluble formula with food. This allows the body the opportunity for maximum absorption into the bloodstream,” Chernoff writes. “The more CBD the body absorbs, the more likely the user is to experience the potential benefits of CBD.”
"This is one of the first studies to examine the potential benefits of CBD on digestion and whether it should be taken with food," NextEvo wrote in a statement about the study. "The study provides significant evidence that consuming CBD with food alters the dynamics of CBD metabolism and increases systemic availability favorably, modifying early insulin and triglyceride responses."
The study also uncovered new evidence for the safety of CBD. The study showed that CBD taken at moderate doses, in this case 30 mg per dose, did not cause physiologically significant changes in markers of liver function, suggesting that CBD likely poses no risk to the liver. Potential limitations of the study identified by the researchers include the small sample size and the fact that all of the test subjects were male, although the authors write that they “had no reason to suspect the potential for gender differences.”
A report on the study, “Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Food Interactions, and Effects on Liver Function,” was published online by the journal Nutrients in May.
Author: A.J. Herrington
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